An Introduction To Polyclonal Antibodies

Polyclonal antibodies (PAbs) are powerful biological tools that are used in the analysis of antigens in a wide variety of research and in vitro diagnostic applications. Traditionally, polyclonal antibodies are raised in large animals such as goats and rabbits.

Immunized animals produce an inherently heterogeneous antibody response and the collected serum recognizes multiple antigenic epitopes. You can also check out Boster Bio featured products online from various sources.

Polyclonal antibodies can be generated more rapidly than monoclonal antibodies (MAbs) and therefore a large number of polyclonal antibodies have been developed against various biological targets. In recent years, the use of affinity purification has improved the quality and effectiveness of polyclonal antibodies.

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Like monoclonal antibodies, PAbs are used in a variety of applications including western blotting, enzyme-linked immunosorbent assays (ELISA), immunohistology, and immunoprecipitation techniques. Polyclonal antibodies are more stable than MAb over a wide pH value and are therefore more suitable for pH-sensitive applications.

ARP American Research Products offers a wide range of internationally recognized polyclonal antibodies. The product range includes high-quality antibodies for research purposes against biological targets of potential diagnostic and therapeutic importance.

Polyclonal antibodies that recognize complement components

The complement system consists of a specific group of proteins that play key roles in the innate immune response, inflammation, and homeostasis. In response to the detection of potential pathogens, inactive complement proteins interact with each other in an enzyme cascade and are activated sequentially.

During this process, protein fragments have been created that act as chemoattractants, adhesion molecules, and opsonins. The complement system can be activated in three different ways 1) Classical way 2) Alternative way 3) The mannose-binding lectin route.